Haplotype and linkage disequilibrium of TP53-WRAP53 locus in Iranian-Azeri women with breast cancer
نویسندگان
چکیده
منابع مشابه
Association of P53 (+16ins-Arg) Haplotype with the Increased Susceptibility to Breast Cancer in Iranian-Azeri Women
Background:Many case-control investigations have showed the correlation of TP53 gene polymorphisms with the risk of breast cancer. However, the findings are not consistent. It has been suggested that the investigation of P53 genotype combinations and haplotypes may be more helpful than the detection of single polymorphisms. In the present study, we investigate...
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BACKGROUND TP53 mutations are the most common genetic alterations in human cancers. There are also several polymorphisms in both exons and introns of TP53 that may influence its anti-tumor functions and increase the risk of cancer development. Associations of the TP53 intron 6 G13964C polymorphism with increased risk of development of several cancers have been investigated in numerous studies, ...
متن کاملLinkage disequilibrium, haplotype evolution, and the coalescent
Linkage disequilibrium has become an important tool for fine-scale mapping. We argue that in order to understand the pattern of association between alleles at different loci, as well as DNA sequence polymorphism, it is useful first to consider the underlying genealogy of the chromosomes. The stochastic process known as the coalescent provides an extremely convenient way of modeling such genealo...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2019
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0220727